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In the past few years, huge data sets with DNA from hundreds of thousands of people have made possible much more powerful studies. Using a big-data technique called genome-wide association, the researchers estimated that common genetic variants — single-letter differences in DNA sequences — account for between 8 percent and 25 percent of same-sex sexual behavior.

Doug Vanderlaan, a University of Toronto psychologist who studies sexual orientation, said the absence of information on sexual orientation is a drawback and makes it unclear what the identified genetic links might signify.

The research also suggests the genetics of same-sex sexual behavior shares some correlation with genes involved in some mental health issues and personality traits — although the authors said that overlap could simply reflect the stress of enduring societal prejudice.

The moment the study was published online Thursday afternoon, the Broad Institute took the unusual step of posting essays by Dr. In addition, genes seemed to have greater influence on same-sex sexual behavior in men than in women, Ganna said.

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